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Jul Ten,  · It was shown that fisetin ties to two sites on the mTOR molecule. The strapping energies were in the −7 to −8 kcal/mol range, and the tying site included hydrogen bonding to a glutamate by two OH groups (Fig. 4A). The proposed mechanism through which fisetin targets mTOR signaling in cancer cells is shown in Figure 4B. Cell culture studies.

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